In this interview, Dr Shalin Naik sits down with Associate Professors Sam Morris and Allon Klein. While they do discuss their science, Shalin dives in and asks the deeper questions . What have been their lightbulb moments? What segues did they make scientifically? Why is single cell more than just a fad for them? What are the big questions in biology in their opinion?

Single-cell analysis technologies have matured rapidly in the last decade and are being applied to many aspects of cancer biology. The next challenge for these technologies will be to find applications with real-world impact. In this episode we consider the likely uses of single-cell analysis in cancer, and discuss how these technologies might be integrated into clinical practice.

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Presentations:

0:07:17 A/ Prof Nicholas Navin - "Clinical Applications of Single Cell Genomics".

0:35:30 Dr Venessa Chin - "Using single cell genomics to personalise cancer treatment".

0:52:50 Dr Charis Teh - "Mass Cytometry (CyTOF) Technology in Cancer Drug Research".

In this episode, we will learn about latest case studies of applying spatial sequencing to study cancer, Covid-19, and tissue biology. We will discuss the complementarity of spatial and single cell sequencing. Is spatial sequencing the “next generation single cell technology”? 

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Presentations:

0:08:05 Prof Itai Yanai - "Exploring cancer cell states using scRNA-Seq and spatial transcriptomics".

0:34:00 Dr Arutha Kulasinghe - "Profiling of the tumour microenvironment using digital spatial profiling".

0:48:34 Arti Raghubar - "Integrating traditional histology with modern spatial transcriptomics (ST)”.

1:01:15 Sunny Wu - "An integrated multi-omic cellular atlas of the breast tumour microenvironment".

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What is Oz Single Cell? What does the future hold for single cell technology in Australia? Are Aussies slow adopters? Are we capitalising on our strengths? What is Australia’s role in global initiatives like the Human Cell Atlas. The Oz Single Cell Community has sent in their questions and you can rely on the inventors of the ChriSNE, DiSNE, Miss Methyl and MINTIE to have some of the answers.

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Where do you come from, where do you go? Hear from Anna Obenauf, Prisca Liberali and Ethan Liu about the latest in lineage tracing, trajectory analysis and cellular fate. Hosted by Shalin Naik and Daniela Zalcenstein

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Taking on immunology research with single cell technologies. Insights from Margaret Nakamoto and Harry Sutton about how single cell technologies are enabling some remarkable research in the field of immunology. Hosted by Helen McGuire and Fabio Luciani.

Taking on immunology research with single cell technologies. Insights from Ellen Rothenberg, Ashraful Haque and Joel Rimes about how single cell technologies are enabling some remarkable research in the field of immunology. Hosted by Helen McGuire and Shalin Naik

This episode discusses new computational approaches for the analysis of single cell data. Hear from Stephanie Hicks, Drew Neavin and Thomas Ashhurst. Hosted by Prof Alicia Oshlack and Dr Quan Nguyen.